The aim of the study is the safe usage of radiation, the lack of proficiency of radiology workers, job satisfaction based on uncertainly, to evaluate depression levels according to sociodemographic characteristics and to find out whether there is any connection between them. The data have been applied to 100 radiology workers in İstanbul; Minessota Job Satisfaction Scale, Beck Depression Scale and Uncertainty Intolerance Scale. Occupational information survey of radiology workers and obtaining sociodemographic form. Participants with a high level of professional knowledge in the study, job satisfaction scores were significantly high, a negative connection was found between the level of professional knowledge and depression between job satisfaction and depression levels. In this study, the level of occupational knowledge, job satisfaction, intolerance to uncertainty and depression levels of the radiology workers were investigated, in addition to raising professional knowledge level of the employees working in the field of radiology, it is also important to develop and disseminate radiation protection ways, to ensure job satisfaction and to reduce the level of depression.